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PF-4708671
Artikelnummer: TGM-T2002-5mg
Description: PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM). Target: S6 Kinase, Autophagy. Smiles: CCc1cncnc1N1CCN(Cc2nc3cc(ccc3[nH]2)C(F)(F)F)CC1. References: Pearce LR, et al. Biochem J,...
| Schlagworte: | PF4708671 |
| CAS | 1255517-76-0 |
| MW: | 390.41 D |
ab 45,00 €
PF-04708671
Artikelnummer: Cay15018-10
P70 ribosomal S6 kinase (S6K1) is a serine/threonine kinase which is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM). It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under...
| Schlagworte: | 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole |
| Anwendung: | S6K1 inhibitor |
| CAS | 1255517-76-0 |
| MW: | 390.4 D |
ab 144,00 €
