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LY2874455
Artikelnummer: Cay20843-25
LY2874455 is a pan-inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases with IC50 values of 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively. It has been shown to inhibit proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor...
| Schlagworte: | 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol |
| Anwendung: | FGFR inhibitor |
| CAS | 1254473-64-7 |
| MW: | 444.3 D |
ab 111,00 €
LY-2874455
Artikelnummer: LKT-L9602.1
LY287445 is an inhibitor of FGFR that exhibits anticancer chemotherapeutic activity. LY287445 inhibits cell proliferation and tumor growth across in vitro and in vivo models of several cancers, including lung cancer, gastric cancer, and multiple myeloma.
| Anwendung: | FGFR inhibitor |
| CAS | 1254473-64-7 |
| MW: | 444.31 D |
ab 234,00 €
LY2874455
Artikelnummer: TGM-T2361-100mg
Description: LY2874455 has been used in trials studying the treatment of Advanced Cancer. Target: VEGFR, FGFR. Smiles: C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl. References: Zhao G, et al. Mol Cancer Ther. 2011, 10(11), 2200-2210.
| Schlagworte: | LY 2874455, LY-2874455 |
| CAS | 1254473-64-7 |
| MW: | 444.31 D |
ab 40,00 €
