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RQ-00203078
Artikelnummer: Cay19075-1
RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8, IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 µM), TRPA1 (IC50 > 10 µM), TRPV4 (IC50 = 10 µM), or TRPM2 channels (IC50 > 10 µM). It attenuates...
| Schlagworte: | 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-benzoic acid |
| Anwendung: | TRPM8 antagonist |
| CAS | 1254205-52-1 |
| MW: | 554.8 D |
ab 51,00 €
RQ-00203078
Artikelnummer: TGM-T2007-100mg
Description: RQ-00203078 is a highly selective, potent, and orally available TRPM8 antagonist. Target: TRP/TRPV Channel. Smiles: OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F. References: Chaussade C, et al. Biochem J, 2007, 404(3), 449-58.
| CAS | 1254205-52-1 |
| MW: | 554.85 D |
ab 41,00 €
