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Tubastatin A
Artikelnummer: Cay15785-5
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a...
| Schlagworte: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide |
| Anwendung: | Potent HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335.4 D |
ab 67,00 €
Tubastatin A
Artikelnummer: AG-CR1-3900-M010
Off-white solid. Soluble in DMSO. Cell permeable potent and selective class IIb histone deacetylase 6 (HDAC6) inhibitor (IC50=15nM, >,1000-fold selective against other HDACs and 60-fold for HDAC8), Neuroprotective. Effectively prevents neuronal cell death (by &ge,95% at 10µ,M) upon oxidative stress induction...
| Schlagworte: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl] benzamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335,4 D |
72,00 €
Tubastatin A
Artikelnummer: TGM-T1966-100mg
Description: Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8. Target: Autophagy, HDAC, Apoptosis. Smiles: CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO. References: Butler KV, et...
| Schlagworte: | Tubastatin A BASE |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335.4 D |
ab 38,00 €
