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URMC-099
Artikelnummer: SYN-1211-M001
Solid. Soluble in DMSO or water. Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinson's disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable...
| Schlagworte: | 3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3- b]pyridine |
| Anwendung: | MLK-3 inhibitor |
| CAS | 1229582-33-5 |
| MW: | 421,5 D |
ab 154,00 €
URMC-099
Artikelnummer: TGM-T6057-100mg
Description: URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). Target: Trk receptor, VEGFR, Syk, Autophagy, Src, IGF-1R, Bcr-Abl, CDK, DNA Alkylation, MLK, LRRK2, MEK, Aurora Kinase, SGK,...
| Anwendung: | MLK inhibitor |
| CAS | 1229582-33-5 |
| MW: | 421.54 D |
ab 49,00 €
URMC-099
Artikelnummer: Cay19147-5
URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively. It also inhibits LRRK2 activity with an IC50 value of 11 nM. In vitro, URMC-099 has been shown to reduce...
| Schlagworte: | 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine |
| Anwendung: | MLK inhibitor |
| CAS | 1229582-33-5 |
| MW: | 421.5 D |
ab 93,00 €
