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Philanthotoxin 74 (hydrochloride)
Artikelnummer: Cay14607-1
Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It...
| Schlagworte: | PhTx-74, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-alphaS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride |
| Anwendung: | Forensic studies |
| CAS | 1227301-51-0 |
| MW: | 507.5 D |
ab 102,00 €
Philanthotoxin 74 dihydrochloride
Artikelnummer: TGM-T16524-1mg
Description: Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1. Target: iGluR, GluR. Smiles: OC(C=C1)=CC=C1C[C@H](NC(CCC)=O)C(NCCCCCCCNC CCCN)=O.Cl.Cl. References: Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing...
| Schlagworte: | PhTx 74 dihydrochloride, PhTx-74 HCl |
| CAS | 1227301-51-0 |
| MW: | 507.54 D |
ab 45,00 €
