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ON-01910 (sodium salt)
Artikelnummer: Cay15553-1
ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1, IC50 = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling. It induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines....
| Schlagworte: | Rigosertib, N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine, monosodium salt |
| Anwendung: | Plk1 inhibitor |
| CAS | 1225497-78-8 |
| MW: | 473.5 D |
ab 52,00 €
(E/Z)-Rigosertib sodium
Artikelnummer: TGM-T6070-100mg
Description: ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a...
| Schlagworte: | (E/Z) ON-01910 sodium |
| Anwendung: | Plk1 inhibitor |
| CAS | 1225497-78-8 |
| MW: | 473.47 D |
ab 33,00 €
