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NPS 1034
Artikelnummer: Cay19627-1
NPS 1034 is a dual inhibitor of the receptor tyrosine kinase activities of MET (IC50 = 48 nM) and AXL (IC50 = 10.3 nM), receptors for hepatocyte growth factor and vitamin K-dependent proteins, respectively. It synergistically inhibits cell proliferation when used in combination with gefitinib (Cay-13166) or...
| Schlagworte: | 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-py... |
| Anwendung: | MET inhibitor |
| CAS | 1221713-92-3 |
| MW: | 551.6 D |
ab 56,00 €
NPS-1034
Artikelnummer: TGM-T6907-100mg
Description: NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. Target: c-Met/HGFR, TAM Receptor, Apoptosis. Smiles: Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C. References: Shin JS, et al. Invest New Drugs. 2014, 32(3), 389-399.
| Schlagworte: | NPS1034 , NPS 1034 |
| Anwendung: | MET inhibitor |
| CAS | 1221713-92-3 |
| MW: | 551.54 D |
ab 30,00 €
