Zu "1218778-77-8" wurden 3 Artikel gefunden!
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LDE225 (phosphate)
Artikelnummer: Cay16263-1
LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively). In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in...
| Schlagworte: | Erismodegib, NVP-LDE225, Sonidegib,... |
| Anwendung: | Smo antagonist |
| CAS | 1218778-77-8 |
| MW: | 681.5 D |
ab 49,00 €
NVP-LDE225 Diphosphate
Artikelnummer: LKT-N8663.1
Smo inhibitor.
| Schlagworte: | Erismodegib, Sonidegib |
| Anwendung: | Smo inhibitor |
| CAS | 1218778-77-8 |
| MW: | 681.49 D |
ab 73,00 €
Sonidegib diphosphate
Artikelnummer: TGM-T15727-100mg
Description: Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). Target: Smo. Smiles: OP(O)(O)=O.OP(O)(O)=O.C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(-c3ccc(OC(F)(F)F)cc3)c2C)cn1. References: Pan...
| Schlagworte: | LDE225 diphosphate, Erismodegib diphosphate, NVP-LDE 225 diphosphate |
| Anwendung: | Targets smoothened (SMO) |
| CAS | 1218778-77-8 |
| MW: | 681.49 D |
ab 41,00 €
