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Oclacitinib
Artikelnummer: Cay18722-1
Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 µM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-alpha levels in murine bone marrow-derived...
| Schlagworte: | PF-03394197, trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide |
| Anwendung: | JAK inhibitor |
| CAS | 1208319-26-9 |
| MW: | 337.4 D |
ab 52,00 €
Oclacitinib
Artikelnummer: TGM-T2012-100mg
Description: Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM, not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). Target: JAK. Smiles: CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12. References: Gonzales AJ, et al. J Vet Pharmacol Ther. 2014...
| Schlagworte: | PF-03394197 |
| CAS | 1208319-26-9 |
| MW: | 337.44 D |
ab 38,00 €
