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AZD 1208
Artikelnummer: Cay20235-1
AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively). It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16...
| Schlagworte: | (5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione |
| Anwendung: | Pim-1 / Pim-2 / Pim-3 inhibitor |
| CAS | 1204144-28-4 |
| MW: | 379.5 D |
ab 44,00 €
AZD1208
Artikelnummer: SYN-1214-M005
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3...
| Schlagworte: | AZD-1208 |
| Anwendung: | Pim kinase inhibitor |
| CAS | 1204144-28-4 |
| MW: | 379,5 D |
ab 92,00 €
AZD-1208
Artikelnummer: LKT-A9708.1
AZD-1208 is a Pim-1 kinase inhibitor that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells, AZD-1208 induces cell cycle arrest and apoptosis, inhibiting phosphorylation of downstream targets such as Bcl-2, 4EBP1, p70S6K, and S6 and suppressing cell growth. In vivo, AZD-1208...
| Anwendung: | Pim-1 kinase inhibitor |
| CAS | 1204144-28-4 |
| MW: | 379.48 D |
ab 248,00 €
