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Cyclotraxin B
Artikelnummer: Cay42991-1
Cyclotraxin B is a cyclic peptide and negative allosteric modulator of tropomysin-related kinase B (TrkB). It inhibits BDNF-induced TrkB activity in a kinase receptor activation ELISA (KIRA-ELISA) using tetracycline-responsive CHO-K1 cells expressing recombinant human TrkB (TetOn-rhTrkB cells, IC50 = 0. nM). It also...
| Schlagworte: | cyclic (1->11)-disulfide... |
| Anwendung: | Cyclic peptide, negative allosteric TrkB modulator |
| CAS | 1203586-72-4 |
| MW: | 1200.37 D |
ab 274,00 €
Cyclotraxin B
Artikelnummer: TGM-TP2068-1mg
Description: Antagonist of TrkB receptors, inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice. References: Constandil et al...
| CAS | 1203586-72-4 |
| MW: | 1200.36 D |
885,00 €
