Zu "1197953-54-0" wurden 3 Artikel gefunden!
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AP26113
Artikelnummer: Cay19778-1
AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087), ceritinib (Cay-19374), and CH5424802 (Cay-18516). AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.Formal Name:...
| Schlagworte: | Brigatinib,... |
| Anwendung: | Dual ALK / EGFR inhibitor |
| CAS | 1197953-54-0 |
| MW: | 584.1 D |
ab 60,00 €
Brigatinib
Artikelnummer: CDX-B0374-M005
White to yellow solid. Soluble in DMSO. Sligthly soluble in ethanol. Insoluble in water. Chemical. CAS: 1197953-54-0. Formula: C29H39ClN7O2P. MW: 584.09. Synthetic. Brigitanib acts as a tyrosine kinase inhibitor with activity against multiple kinases including ALK, ROS1, insulin-like growth factor 1 receptor and...
| Schlagworte: | AP26113,... |
| CAS | 1197953-54-0 |
| MW: | 584,09 D |
ab 91,00 €
Brigatinib, Free Base
Artikelnummer: LC-B-9800_100mg
Soluble in DMSO. Brigatinib, also known as AP26113, inhibited ALK, IGF-1R, and InsR kinases with IC50 values of 0.37 nM, 24.9 nM, and 196 nM, respectively. It blocked the viability of Karpas 299 cells (ALK+) with an IC50 of 29 nM in vitro. It demonstrated efficacy in multiple ALK+ xenografts in mice, including...
| Schlagworte: | AP26113 |
| Anwendung: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1197953-54-0 |
| MW: | 584.09 D |
ab 82,00 €
