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UNC0224
Artikelnummer: Cay13631-5
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is...
| Schlagworte: | 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolin... |
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1197196-48-7 |
| MW: | 485.7 D |
ab 74,00 €
UNC0224
Artikelnummer: TGM-T17203-100mg
Description: UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. Target: Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCCN(C)C)N1CCCN(C)CC1. References: Liu F, et al. Protein lysine...
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1197196-48-7 |
| MW: | 485.67 D |
ab 45,00 €
