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MK-8617
Artikelnummer: TGM-T4106-100mg
Description: MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: COc1ccc(cc1)C(NC(=O)c1cnc([nH]c1=O)-c1cccnn1)c1ccc(OC)cc1. References: John S. Debenham, et al. J Med Chem. 2016, 59 (24):11039-11049.
| Schlagworte: | MK8617 |
| Anwendung: | Pan HIF-PH inhibitor |
| CAS | 1187990-87-9 |
| MW: | 443.45 D |
ab 31,00 €
MK-8617
Artikelnummer: Cay33790-5
MK-8617 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 1 (HIF-PH1), HIF-PH2, and HIF-PH3 (IC50s = 1, 1, and 14 nM, respectively). It is selective for HIF-PH1, -2, and -3 over the cytochrome P450 (CYP) isoforms CYP1A2, -3A4, -2B6, -2C9, -2C19, and -2D6 (IC50s = >1.6 µM for all) and factor inhibiting...
| Schlagworte: | N-[bis(4-methoxyphenyl)methyl]-1,6-dihydro-6-oxo-2-(3-pyridazinyl)-5-pyrimidinecarboxamide |
| Anwendung: | Pan HIF-PH inhibitor |
| CAS | 1187990-87-9 |
| MW: | 443.5 D |
ab 67,00 €
