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Raltitrexed
Artikelnummer: Cay26079-10
Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM). It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg,...
| Schlagworte: | ICI-D 1694, ZD 1694, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic... |
| Anwendung: | Antineoplastic, thymidylate synthase inhibitor |
| CAS | 112887-68-0 |
| MW: | 458.5 D |
ab 93,00 €
Raltitrexed
Artikelnummer: LKT-R0245.10
An antimetabolite drug used in cancer chemotherapy which is an inhibitor of thymidylate synthase.
| Anwendung: | Thymidylate synthase inhibitor |
| CAS | 112887-68-0 |
| MW: | 458,49 D |
ab 175,00 €
Raltitrexed
Artikelnummer: TGM-T6632-100mg
Description: Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth. Target: DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog. Smiles: O=C1C=2C(=CC=C(CN(C)C=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3)C2)NC(C)=N1. References: Peters GJ, et al. Eur J Cancer,...
| Schlagworte: | Tomudex, ZD1694, D1694, ICI-D1694 |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 112887-68-0 |
| MW: | 458.49 D |
ab 30,00 €
