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NEU
SR 3306
Artikelnummer: Cay45342-1
SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively). It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or...
| Schlagworte: | N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]-2-pyrimidinamine |
| Anwendung: | Pan-JNK inhibitor |
| CAS | 1128096-91-2 |
| MW: | 490.57 D |
ab 55,00 €
SR-3306
Artikelnummer: TGM-T16927-100mg
Description: SR-3306 is a potent and highly inhibitor of brain penetrant JNK. Target: JNK. Smiles: Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1. References: Crocker CE, et al. JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of...
| CAS | 1128096-91-2 |
| MW: | 490.56 D |
ab 42,00 €
