Zu "1125632-93-0" wurden 3 Artikel gefunden!
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Takeda-6d
Artikelnummer: SYN-1168-M001
Soluble in DMSO. Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM. Target: B-RAF - VEGFR2 , Kinase Group: TKL , Substrate: Serine-Threonine
| Schlagworte: | Takeda 6d |
| Anwendung: | B-RAF / VEGFR2 inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
ab 300,00 €
Takeda-6d
Artikelnummer: Cay35754-1
Takeda-6d is a dual inhibitor of RAF kinases and VEGFR2. It inhibits wild-type B-RAF, mutant B-RAFV600E, and C-RAF (IC50s = 12, 7, and 1.5 nM, respectively), as well as VEGFR2 (IC50 = 2.8 nM). Takeda-6d is selective for these kinases over a panel of 19 additional kinases (IC50s = >1,000 nM) but does inhibit FGFR3,...
| Schlagworte: | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino][5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-benzamide |
| Anwendung: | RAF kinases and VEGFR2 dual inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
ab 213,00 €
Takeda-6d
Artikelnummer: TGM-T22436-100mg
Description: Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively. Target: PERK, Raf, VEGFR. Smiles: Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)cc1NC(=O)c1cccc(c1Cl)C1(CC1)C#N
| Anwendung: | RAF kinases and VEGFR2 dual inhibitor |
| CAS | 1125632-93-0 |
| MW: | 547.99 D |
ab 93,00 €
