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Ruxolitinib . phosphate salt
Artikelnummer: AG-CR1-3645-M100
White to off-white solid. Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol. Water-soluble phosphate salt of Ruxolitinib, Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1?/?JAK2 inhibitor |
| CAS | 1092939-17-7 |
| MW: | 404,4 D |
ab 44,00 €
Ruxolitinib (phosphate)
Artikelnummer: Cay23215-10
Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively, and is relatively less selective for JAK3 (IC50 = 322 nM). It blocks interleukin-6 (IL-6) signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM). In primary cultures,...
| Schlagworte: | INC 424 (phosphate), INCB 018424 (phosphate),... |
| Anwendung: | Janus kinase inhibitor |
| CAS | 1092939-17-7 |
| MW: | 404.4 D |
ab 49,00 €
Ruxolitinib phosphate
Artikelnummer: TGM-T3043-100mg
Description: Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Target: Autophagy, Mitophagy, JAK. Smiles: OP(O)(O)=O.N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12....
| Schlagworte: | INCB018424, INC 424 phosphate, INC424, INCB018424 phosphate, Ruxolitinib (INCB-18424) phosphate |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1092939-17-7 |
| MW: | 404.36 D |
ab 42,00 €
