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PF-04447943
Artikelnummer: Cay24299-25
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. It is over 1,000-fold more selective for PDE9A over 79 non-PDE targets, with the exception of the melatonin MT3/ML2...
| Schlagworte: | 1,5-dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyr... |
| Anwendung: | PDE9A inhibitor |
| CAS | 1082744-20-4 |
| MW: | 395.5 D |
ab 54,00 €
PF-04447943
Artikelnummer: TGM-T16478-10mg
Description: PF-04447943 (Edelinontrine) is a potent and selective phosphodiesterase 9A inhibitor with an IC50 of 12 nM, which is 78-fold more selective than that used for other PDE family members (IC50>1000 nM).PF-04447943 exhibits anti-inflammatory activity, attenuates inflammatory responses by inhibiting...
| Schlagworte: | PF04447943, Edelinontrine, PF 04447943 |
| Anwendung: | PDE9A inhibitor |
| CAS | 1082744-20-4 |
| MW: | 395.46 D |
ab 70,00 €
