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ML347
Artikelnummer: TGM-T1943-100mg
Description: ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. Target: ALK, TGF-beta/Smad. Smiles: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12. References: Engers DW, et al. Bioorg Med Chem Lett. 2013, 23(11), 3248-3252.
| Schlagworte: | LDN 193719 |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1062368-49-3 |
| MW: | 352.39 D |
ab 34,00 €
ML-347
Artikelnummer: Cay17640-1
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. ML-347 is a 5-quinoline compound...
| Schlagworte: | LDN193719, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | ALK1 / ALK2 inhibitor |
| CAS | 1062368-49-3 |
| MW: | 352.4 D |
ab 52,00 €
