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MK6-83
Artikelnummer: Cay21944-1
MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes...
| Schlagworte: | 5-methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
| Anwendung: | MCOLN3 agonist |
| CAS | 1062271-24-2 |
| MW: | 336.5 D |
ab 51,00 €
MK6-83
Artikelnummer: TGM-T24477-100mg
Description: MK6-83 is the transient receptor potential channel ML3 agonist. Target: TRP/TRPV Channel. Smiles: Cc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1. References: Chen CC, Keller M et al. A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat Commun. 2014 Aug 14,5:4681.
| Schlagworte: | MK683 |
| CAS | 1062271-24-2 |
| MW: | 336.47 D |
ab 39,00 €
