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Ro3280
Artikelnummer: TGM-T2634-100mg
Description: Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM). Target: PLK. Smiles: COc1cc(ccc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1. References: Chen S, et al. Bioorg Med Chem Lett, 2012, 22(2), 1247-1250.
| Schlagworte: | RO 3280, Ro5203280 |
| CAS | 1062243-51-9 |
| MW: | 543.61 D |
ab 55,00 €
Ro 3280
Artikelnummer: Cay21669-1
Ro 3280 is a selective inhibitor of polo-like kinase 1 (Plk1), a proto-oncogene, with IC50 values of 3 and 6 nM in an enzymatic assay and H82 lung cancer cells, respectively. Ro 3280 is over 500-fold selective for PlK1 over a panel of 318 kinases. It inhibits tumor growth in a mouse xenograft model using the HT-29...
| Schlagworte: | 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(... |
| Anwendung: | Plk1 inhibitor |
| CAS | 1062243-51-9 |
| MW: | 543.6 D |
ab 45,00 €
