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GNE-477
Artikelnummer: SYN-1148-M001
Soluble in DMSO. GNE 477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC(50) value of 4nM and 21nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | GNE477 |
| Anwendung: | PI3K / mTOR inhibitor |
| CAS | 1032754-81-6 |
| MW: | 504,6 D |
ab 300,00 €
GNE-477
Artikelnummer: Cay27977-10
GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kalpha) and mTOR (apparent Ki = 21 nM). It inhibits proliferation of MCF-7.1 cells with an EC50 value of 143 nM. It reduces tumor growth in a PC3-NCI tumor xenograft model when administered at doses ranging from 1 to 20 mg/kg per day.Formal Name:...
| Schlagworte: | 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-2-pyrimidinamine |
| Anwendung: | PI3K inhibitor, mTOR inhibitor |
| CAS | 1032754-81-6 |
| MW: | 504.6 D |
ab 243,00 €
GNE-477
Artikelnummer: TGM-T3692-100mg
Description: GNE-477 is a potent and efficacious dual (PI3K/mTOR) inhibitor. Target: PI3K, mTOR. Smiles: Cc1c(CN2CCN(CC2)S(C)(=O)=O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1. References: Heffron TP, et al. Bioorg Med Chem Lett. 2010 Apr 15,20(8):2408-11.
| Schlagworte: | GNE 477 |
| Anwendung: | PI3K inhibitor, mTOR inhibitor |
| CAS | 1032754-81-6 |
| MW: | 504.63 D |
ab 60,00 €
