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SGX523
Artikelnummer: Cay18093-25
The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases....
| Schlagworte: | 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-quinoline |
| Anwendung: | c-Met inhibitor |
| CAS | 1022150-57-7 |
| MW: | 359.4 D |
ab 67,00 €
SGX-523
Artikelnummer: LKT-S2792.1
SGX-523 is an inhibitor of MET that exhibits anticancer chemotherapeutic activity. SGX-523 inhibits growth of cells and tumors in models of non-small cell lung cancer (NSCLC). SGX-523 also improves the efficacy of co-administered treatments, further suppressing growth in animal models of lung cancer, breast cancer,...
| Schlagworte: | SGX523 |
| Anwendung: | c-MET inhibitor |
| CAS | 1022150-57-7 |
| MW: | 359.41 D |
ab 94,00 €
SGX-523
Artikelnummer: TGM-T2293-100mg
Description: SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38alpha, and c-Raf. Target: p38 MAPK, Raf, c-Met/HGFR, Bcr-Abl. Smiles: Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1
| CAS | 1022150-57-7 |
| MW: | 359.41 D |
ab 30,00 €
