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3-Deazaneplanocin A
Artikelnummer: Cay13828-1
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
| Schlagworte: | DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Anwendung: | S-adenosyl-L-homosysteine hydrolase inhibitor |
| CAS | 102052-95-9 |
| MW: | 262.3 D |
ab 149,00 €
3-Deazaneplanocin A
Artikelnummer: TGM-T6292-1mg
Description: 3-Deazaneplanocin A (DZNep) is a dual inhibitor of histone methyltransferase (EZH2) and S-adenosylhomocysteine hydrolase (AHCY) with antipoxidative activity that inhibits hepatic, renal, peritoneal, and airway fibrosis by inducing proteasomal degradation of its targets and reducing toxicity in animal...
| Schlagworte: | 3-Deazaneplanocin , DZNep |
| CAS | 102052-95-9 |
| MW: | 262.26 D |
ab 122,00 €
