Zu "1020315-31-4" wurden 2 Artikel gefunden!
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PF-04457845
Artikelnummer: Cay19306-5
PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH, IC50 = 7.2 nM) that is selective against other serine hydrolases. It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH. In a rat model of inflammatory pain, oral administration of 0.1 mg/kg...
| Schlagworte: | N-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide |
| Anwendung: | Irreversible FAAH inhibitor |
| CAS | 1020315-31-4 |
| MW: | 455.4 D |
ab 102,00 €
PF-04457845
Artikelnummer: TGM-T4323-100mg
Description: PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM). Target: FAAH, Autophagy. Smiles: FC(F)(F)c1ccc(Oc2cccc(C=C3CCN(CC3)C(=O)Nc3cccnn3)c2)nc1. References: Johnson DS, et al. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and...
| Schlagworte: | PF 04457845, PF04457845 |
| Anwendung: | Irreversible FAAH inhibitor |
| CAS | 1020315-31-4 |
| MW: | 455.43 D |
ab 30,00 €
