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Gefapixant
Artikelnummer: Cay40825-1
Gefapixant is an allosteric antagonist of the purinergic P2X3 receptor. It inhibits agonist-induced P2X3 and P2X2/3 currents in 1321N1 cells co-expressing human P2X2 and P2X3 (IC50s = 153 and 220 nM, respectively) but does not inhibit P2X2 currents in the same cells at 10 µM. In vivo, gefapixant (30 mg/kg) increases...
| Schlagworte: | AF-219, MK-7264, Ro 4926219, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-benzenesulfonamide |
| Anwendung: | P2X3 receptor antagonist, analgesic, antitussive |
| CAS | 1015787-98-0 |
| MW: | 353.4 D |
ab 38,00 €
Gefapixant
Artikelnummer: TGM-T5099-100mg
Description: Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Target: P2X Receptor. Smiles: COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O. References: Ford AP, In pursuit of P2X3 antagonists: novel...
| Schlagworte: | RO 4926219 , AF219 , MK-7264 |
| Anwendung: | Targets P2X purinoceptor 3 (P2RX3) |
| CAS | 1015787-98-0 |
| MW: | 353.4 D |
ab 31,00 €
