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MK-5108
Artikelnummer: TGM-T6068-100mg
Description: MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM. Target: Autophagy, Aurora Kinase. Smiles: OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F. References: Shimomura T, et al. Mol Cancer Ther. 2010, 9(1), 157-166.
| Schlagworte: | MK5108, VX-689 |
| Anwendung: | Aurora A inhibitor |
| CAS | 1010085-13-8 |
| MW: | 461.94 D |
ab 34,00 €
MK-5108
Artikelnummer: Cay19167-5
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM). It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis...
| Schlagworte: | VX-689, trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid |
| Anwendung: | Aurora A inhibitor |
| CAS | 1010085-13-8 |
| MW: | 461.9 D |
ab 78,00 €
