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TC ASK 10
Artikelnummer: TGM-T13099-100mg
Description: TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 µM. Target: ASK, MAPK. Smiles: Cl.Cl.CC(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-n1ccnc1. References: Terao Y, et al. Design and biological evaluation of...
| Anwendung: | ASK1 (MEKK5, MAP3K5) inhibitor |
| CAS | 1005775-56-3 |
| MW: | 432.35 D |
ab 30,00 €
ASK1 Inhibitor 10
Artikelnummer: Cay28512-1
ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 14 nM). It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKbeta, ERK1, JNK1, p38alpha, GSK3beta, PKCtheta, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced...
| Schlagworte: | 4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-benzamide, dihydrochloride |
| Anwendung: | ASK1 (MEKK5, MAP3K5) inhibitor |
| CAS | 1005775-56-3 |
| MW: | 432.4 D |
ab 44,00 €
