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GSK-1482160
Artikelnummer: TGM-T61025-100mg
Description: GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows...
| CAS | 1001389-72-5 |
| MW: | 334.72 D |
ab 30,00 €
GSK1482160
Artikelnummer: Cay41980-10
A P2X7 receptor antagonist (IC50 = 3.2 nM for the human receptor), inhibits LPS- and BzATP-induced increases in ROS levels in THP-1 macrophages at 1 µM, decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human...
| Schlagworte: | (2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxo-2-pyrrolidinecarboxamide |
| Anwendung: | P2X7 receptor antagonist |
| CAS | 1001389-72-5 |
| MW: | 334.72 D |
ab 120,00 €
