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GDC-0068
Artikelnummer: Cay18412-1
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays. It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by...
| Schlagworte: | Ipatasertib, RG-7440,... |
| Anwendung: | Akt (protein kinase B) inhibitor |
| CAS | 1001264-89-6 |
| MW: | 458 D |
ab 85,00 €
GDC-0068
Artikelnummer: LKT-G1200.1
GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (PKB, protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway.
| Schlagworte: | RG7440, Ipatasertib |
| Anwendung: | AKT inhibitor |
| CAS | 1001264-89-6 |
| MW: | 458 D |
ab 109,00 €
Ipatasertib
Artikelnummer: TGM-T6252-100mg
Description: Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively. Target: Akt. Smiles: C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3. References: Lin K. Cancer Res, 2011, 71(8 Supplement), abstract DDT02-01.
| Schlagworte: | GDC-0068, RG7440 |
| Anwendung: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1001264-89-6 |
| MW: | 458 D |
ab 38,00 €
