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Apramycin (sulfate hydrate)
Artikelnummer: Cay19688-5
Apramycin is an aminoglycoside antibiotic first isolated from S. tenebrarius. It is active against a variety of Gram-positive and Gram-negative bacteria, including strains which produce aminoglycoside-modifying enzymes. Apramycin inhibits protein synthesis in bacteria both in vivo and in vitro.Formal Name:...
| Schlagworte: | Nebramycin II,... |
| Anwendung: | Antibiotic |
| MW: | 539.6 D |
ab 45,00 €
Cordycepin
Artikelnummer: LKT-C5968.100
A nucleoside that was first isolated from the cultures of cordyceps militaris. It was found to inhibit Ehrlich mouse ascites tumors. Recent findings suggest cordycepin activates adenosine subtype receptors and simultaneously induce steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells. It also inhibit...
| Schlagworte: | 3'-deoxyadenosine |
| Anwendung: | Inhibits Ehrlich mouse ascites tumors |
| CAS | 73-03-0 |
| MW: | 251,24 D |
ab 155,00 €
Anti-SAPS1
Artikelnummer: A300-968A-T
Protein function: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. [The UniProt Consortium]
| Schlagworte: | Anti-PPP6R1, Anti-KIAA1115, Anti-SAPS domain family member 1, Anti-Serine/threonine-protein phosphatase 6 regulatory... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Cetirizine (hydrochloride)
Artikelnummer: Cay19686-1
Cetirizine is a bioactive carboxylated metabolite of hydroxyzine (Cay-24039) that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM). As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit. Cetirizine is a racemic mixture composed...
| Schlagworte: | UCB-P 071, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid, dihydrochloride |
| Anwendung: | H1-receptor antagonist |
| CAS | 83881-52-1 |
| MW: | 461.8 D |
ab 58,00 €
Foretinib
Artikelnummer: LKT-F5968.5
Foretinib is an inhibitor of ROS1, MET, Ron, Axl, Tie-2, and VEGFR2 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In subjects with squamous cell carcinoma, foretinib decreases tumor size. In hepatocellular carcinoma cells, foretinib increases expression of p27 and Bim, decreases...
| Schlagworte: | GSK-1363089, GSK1363089 |
| Anwendung: | VEGFR2 tyrosine kinase inhibitor, Met proto-oncogene (c-Met) inhibitor |
| CAS | 849217-64-7 |
| MW: | 632.65 D |
ab 151,00 €
UNC1215
Artikelnummer: Cay13968-1
Methyllysine (Kme) recognition "reader" domains play a central role in epigenetic regulation during cellular differentiation, development, and gene transcription. UNC1215 is a potent and selective chemical probe for the Kme reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin...
| Schlagworte: | (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone) |
| Anwendung: | L3MBTL3 probe |
| CAS | 1415800-43-9 |
| MW: | 529.7 D |
ab 74,00 €
ZM 306416
Artikelnummer: Cay16968-5
ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 µM, respectively. It has also been reported to inhibit EGFR kinase with an IC50 value of 98%. Formulation: (Request formulation...
| Schlagworte: | CB-676475, N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine |
| Anwendung: | VEGFR inhibitor |
| CAS | 690206-97-4 |
| MW: | 333.7 D |
ab 69,00 €
Boc-Lys(Ac)-AMC
Artikelnummer: Cay29682-10
Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs). Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm,...
| Schlagworte: | N-[(1S)-5-(acetylamino)-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]pentyl]-carbamic acid, 1,1-dimethylethyl... |
| Anwendung: | Fluorogenic HDAC substrate |
| CAS | 233691-67-3 |
| MW: | 445.5 D |
ab 87,00 €
Purpurogallin
Artikelnummer: Cay29689-50
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Cay-20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S....
| Schlagworte: | NCI 35676, NSC 35676, NSC 646653, 2,3,4,6-tetrahydroxy-5H-benzocyclohepten-5-one |
| Anwendung: | Bioactive pyrogallol derivative |
| CAS | 569-77-7 |
| MW: | 220.2 D |
ab 59,00 €
(±)-4-CMTB
Artikelnummer: Cay29680-5
(±)-4-CMTB is a positive allosteric modulator of free fatty acid receptor 2 (FFAR2/GPR43) with an EC50 value of 0.42 µM for [35S]GTPgammaS binding to 293 T-REx cell membranes expressing the human receptor. It selectively induces ERK1/2 phosphorylation in 293 T-REx cells expressing human FFAR2, but not FFAR1 or...
| Schlagworte: | 4-chloro-alpha-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide |
| Anwendung: | FFAR2/GPR43 positive allosteric modulator |
| CAS | 300851-67-6 |
| MW: | 294.8 D |
ab 180,00 €
Anti-Collagen IV
Artikelnummer: ARG21968.100
Protein function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. [The UniProt Consortium]
| Schlagworte: | Anti-COL4A1 |
| Anwendung: | ELISA, FLISA, IHC (paraffin), IHC (frozen), ICC, IF, EM, FC, WB, IP |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, bovine, mouse, rat |
658,00 €