Zu "925," wurden 71 Artikel gefunden!
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AMG 925 HCl
Artikelnummer: TGM-T63487-500mg
Description: AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM). Target: Others. Smiles: N(C=1N=C2N(C=3C(C2=CN1)=CC=NC3)[C@H]4CC[C@H](C)CC4)C=5N=C6C(=CC5)CN(C(CO)=O)CC6.Cl
| CAS | 1401034-19-2 |
| MW: | 508.02 D |
1.127,00 €
AMG 925
Artikelnummer: Cay29245-5
AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4, IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 µM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits...
| Schlagworte: | 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6... |
| Anwendung: | FLT3 / Cdk4 dual inhibitor |
| CAS | 1401033-86-0 |
| MW: | 471.6 D |
ab 49,00 €
AMG 925
Artikelnummer: TGM-T6756-10mg
Description: AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. Target: CDK, FLT. Smiles: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12. References: Xiaoqi Chen, et al. Fused tricyclic dual inhibitors of cdk 4/6 and flt3. WO 2012129344 A1
| Anwendung: | FLT3 / Cdk4 dual inhibitor |
| CAS | 1401033-86-0 |
| MW: | 471.55 D |
ab 30,00 €
Moexipril (hydrochloride)
Artikelnummer: Cay21255-10
Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for...
| Schlagworte: | CI-925, RS 10085-197, SPM 925,... |
| Anwendung: | ACE inhibitor |
| CAS | 82586-52-5 |
| MW: | 535 D |
ab 67,00 €
PathPlex(TM) Panel 7 (CD8 alpha, Cytokeratin, CD45RO,...
Artikelnummer: A810-007
PathPlex Panel 7 identifies total cytotoxic T-cells (CD8), T-helper cells (CD4), memory T-cells (CD45RO) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Tumor cells are identified by cytokeratin.
| Schlagworte: | GeneID 925, 3858, 3861, 3866, 3868, 3880, 5788, 920, 50943 |
| Anwendung: | IHC-IF, mIF |
| Spezies-Reaktivität: | human |
2.527,00 €
PathPlex(TM) Panel 4 (CD3E, Cytokeratin, CD8 alpha, CD68,...
Artikelnummer: A810-004
PathPlex Panel 4 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin) express immune checkpoint ligands such as PD-L1 which inhibits the ability of...
| Schlagworte: | GeneID 916, 925, 968, 29126, 50943, 3858, 3861, 3866, 3868, 3880 |
| Anwendung: | IHC-IF, mIF |
| Spezies-Reaktivität: | human |
3.032,00 €
PathPlex(TM) Panel 5 (CD3E, Cytokeratin, CD8 alpha, CD68,...
Artikelnummer: A810-005
PathPlex Panel 5 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and cells expressing the immune checkpoint ligand PD-L1 within the context of the tumor microenvironment. PD-L1 can be expressed on antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin). Ki-67 is a proliferation...
| Schlagworte: | GeneID 916, 925, 968, 4288, 29126, 3858, 3861, 3866, 3868, 3880 |
| Anwendung: | IHC-IF, mIF |
| Spezies-Reaktivität: | human |
3.032,00 €
NEU
Fulzerasib
Artikelnummer: TGM-T73190-10mg
Description: Fulzerasib is an orally active KRAS G12C inhibitor that covalently binds to the cysteine residue on the protein, thereby inhibiting the growth of KRAS G12C mutant tumour cell lines, with an IC50 of 2â?"20 nM, and can be used to treat KRAS G12C mutant non-small cell lung cancer (NSCLC). Target: Ras,...
| Schlagworte: | GFH 925 |
| MW: | 617.07 D |
ab 152,00 €
PathPlex(TM) Panel 8 (CD3E, Cytokeratin, CD8 alpha, CD4,...
Artikelnummer: A810-008
PathPlex Panel 8 identifies total T-cells (CD3), T-helper cells (CD4), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the tumor microenvironment. Lag3 is a checkpoint inhibitor which identifies exhausted T-cells. Tumor cells are identified by cytokeratin.
| Schlagworte: | GeneID 916, 3858, 3861, 3866, 3868, 3880, 925, 920, 3902, 50943 |
| Anwendung: | IHC-IF, mIF |
| Spezies-Reaktivität: | human |
3.032,00 €
PathPlex(TM) Panel 6 (CD3E, Granzyme B, CD8 alpha,...
Artikelnummer: A810-006
PathPlex Panel 6 identifies total T-cells (CD3) and cytotoxic T-cells (CD8) and activated cytotoxic T-cells (Granzyme B) within the tumor microenvironment. The inclusion of multiple tumor cell makers (cytokeratin, Sox10 and Ki-67) provides flexibility across multiple tumor types.
| Schlagworte: | GeneID 3880, 3868, 3866, 3861, 3858, 916, 3002, 925, 4288, 6663 |
| Anwendung: | IHC-IF, mIF |
| Spezies-Reaktivität: | human |
3.032,00 €
ADR-925
Artikelnummer: TGM-T29670-5mg
Description: ADR-925 (ICRF 198), an active chelated iron metabolite of dexrazoxane, has the ability to protect neonatal rat cardiomyocytes from adriamycin-induced injury. Target: Endogenous Metabolite. Smiles: N([C@H](CN(CC(N)=O)CC(O)=O)C)(CC(N)=O)CC(O)=O. References: Jirkovský E, et al. Pharmacokinetics of the...
| Schlagworte: | ICRF198, ICRF-198, ICRF 198, ADR 925, ADR925 |
| CAS | 75459-34-6 |
| MW: | 304.3 D |
ab 1.061,00 €
Anti-CCD8A (Cytotoxic- & Suppressor T-Cell Marker),...
Artikelnummer: NEO-925-MSM20-P1ABX
Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Cell membrane, Secreted. Positive Control: HuT78 or hPBL cells. Human lymph node or tonsil. Chromosome Location: 2p11.2. Protein Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves...
| Schlagworte: | Anti-CD8A, Anti-T-cell surface glycoprotein CD8 alpha chain, Anti-T-lymphocyte differentiation antigen T8/Leu-2, 559 |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
704,00 €