TRAF2 protein-GST fusion Epitope

Recombinant full-length human TRAF2 was expressed by baculovirus in Sf9 insect cells using an N-Terminal his epitope. The purity was determined to be >80% by densitometry. TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-kB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2). TRAF2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, and NfkB Pathway research.