SET7/9 (human recombinant)

Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.Synonyms: KMT7, SETD7, SETD7/9, SET Domain-containing Protein 7/9. Purity: >95% estimated by SDS-PAGE. Source: Active recombinant N-terminal His-tagged SET7/9 purified from E. coli. Amino Acids: 1-366 (full-length). MW: 43.3 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol. UniProt Accession #: Q8WTS6.