SEMA4B Protein, Mouse, Recombinant (His)

Description: Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. References: Jian H, et al. SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo. Cell Signal. 2015 Jun,27(6):1208-13. doi: 10.1016/j.cellsig.2015.02.027. Epub 2015 Mar 4. PMID: 25746385.