Recombinant Human TRMT2A Protein

Tag: C-His. Modification: unmodified. Start Site: Lys11. End Site: Glu160. Coverage: 0.26. Isoelectric Point: 9.5. Core Sequence: KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 77%, Pig - 72%, Cynomolgus monkey - 97%, Protein Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281) [The Uniprot Consortium]