Recombinant Human TADA2A Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Pro11. End Site: Asn130. Coverage: 0.27. Isoelectric Point: 5. Core Sequence: PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN QMCTKTKEEC EKHYMKHFIN NPLFASTLLN. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 99%, Rat - 100%, Pig - 100%, Cynomolgus monkey - 100%, Protein Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376) [The Uniprot Consortium]