Recombinant Human SH3BP4 Protein

Tag: C-His. Modification: unmodified. Start Site: Ser11. End Site: Phe170. Coverage: 0.17. Isoelectric Point: 6. Core Sequence: SNGLPRCKSE GTLIDLSEGF SETSFNDIKV PSPSALLVDN PTPFGNAKEV IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS DSGMIDNLPD SPDEVAKELE LLGGWTDDKK VPGRMYSNNP FWNGVQTNPF. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 93%, Rat - 95%, Pig - 92%, Cynomolgus monkey - 98%, Protein Function: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy [The Uniprot Consortium]