Recombinant Human RIT1 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Glu21. End Site: Val190. Coverage: 0.79. Isoelectric Point: 5.5. Core Sequence: EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL ALAREFSCPF FETSAAYRYY IDDVFHALVR EIRRKEKEAV. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 98%, Rat - 74%, Pig - 99%, Cynomolgus monkey - 100%, Protein Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation [The Uniprot Consortium]