Recombinant Human PUM3 Protein

Tag: N-His. Modification: unmodified. Start Site: Gly11. End Site: Gln140. Coverage: 0.21. Isoelectric Point: 11.5. Core Sequence: GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS RNFEKSITKL GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS DESAAKKPKW DDFKKKKKEL KQSRQLSDKT NYDIVVRAKQ. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 82%, Rat - 80%, Pig - 82%, Cynomolgus monkey - 95%, Protein Function: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity) [The Uniprot Consortium]