Recombinant Human MTHFR Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Cys131. End Site: Cys250. Coverage: 0.18. Isoelectric Point: 5.5. Core Sequence: CRQRLEEITG HLHKAKQLGL KNIMALRGDP IGDQWEEEEG GFNYAVDLVK HIRSEFGDYF DICVAGYPKG HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV KACTDMGITC. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 84%, Pig - 85%, Cynomolgus monkey - 98%, Protein Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable) [The Uniprot Consortium]