Recombinant Human MTHFR Protein

Tag: C-His. Modification: unmodified. Start Site: Leu11. End Site: Met110. Coverage: 0.16. Isoelectric Point: 7. Core Sequence: LNPCLEGSAS SGSESSKDSS RCSTPGLDPE RHERLREKMR RRLESGDKWF SLEFFPPRTA EGAVNLISRF DRMAAGGPLY IDVTWHPAGD PGSDKETSSM. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 87%, Pig - 85%, Cynomolgus monkey - 95%, Protein Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable) [The Uniprot Consortium]