Recombinant Human MTARC2 Protein

Tag: N-His. Modification: unmodified. Start Site: Leu51. End Site: Val180. Coverage: 0.49. Isoelectric Point: 10.5. Core Sequence: LQQVGTVAKL WIYPVKSCKG VPVSEAECTA MGLRSGNLRD RFWLVIKEDG HMVTARQEPR LVLISIIYEN NCLIFRAPDM DQLVLPSKQP SSNKLHNCRI FGLDIKGRDC GNEAAKWFTN FLKTEAYRLV. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 75%, Rat - 72%, Pig - 80%, Cynomolgus monkey - 97%, Protein Function: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045) [The Uniprot Consortium]