Recombinant Human HEXB Protein

Tag: C-His. Modification: unmodified. Start Site: Ala43. End Site: Met556. Coverage: 1. Isoelectric Point: 7. Core Sequence: ARAPSVSAKP GPALWPLPLL VKMTPNLLHL APENFYISHS PNSTAGPSCT LLEEAFRRYH GYIFGFYKWH HEPAEFQAKT QVQQLLVSIT LQSECDAFPN ISSDESYTLL VKEPVAVLKA NRVWGALRGL ETFSQLVYQD SYGTFTINES TIIDSPRFSH RGILIDTSRH YLPVKIILKT LDAMAFNKFN VLHWHIVDDQ SFPYQSITFP ELSNKGSYSL SHVYTPNDVR MVIEYARLRG IRVLPEFDTP GHTLSWGKGQ KDLLTPCYSR QNKLDSFGPI NPTLNTTYSF LTTFFKEISE VFPDQFIHLG GDEVEFKCWE SNPKIQDFMR QKGFGTDFKK LESFYIQKVL DIIATINKGS IVWQEVFDDK AKLAPGTIVE VWKDSAYPEE LSRVTASGFP VILSAPWYLD LISYGQDWRK YYKVEPLDFG GTQKQKQLFI GGEACLWGEY VDATNLTPRL WPRASAVGER LWSSKDVRDM DDAYDRLTRH RCRMVERGIA AQPLYAGYCN HENM. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 78%, Rat - 76%, Pig - 70%, Cynomolgus monkey - 96%, Protein Function: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity) [The Uniprot Consortium]