PTP alpha/PTPRA, His, Human

The receptor protein-tyrosine phosphatase alpha (encoded by PTPRA), a 130-kDa transmembrane PTP, has shown to be a physiological regulator for PTK c-Src and the kinases involved in integrin signaling pathway including FAK and P130cas. The activation of PTPRA on Src Y530 dephosphorylation led to cellular transformation, which suggested that PTPRA might be an oncogenic gene.