Netrin-1 (human) (rec.)

3 x 10 µg. Human netrin-1 (amino acids 25-604) is fused at the N-terminus to a FLAG(R)-tag. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.