Mouse ST2, recombinant (V192A, C-Fc)

Recombinant Mouse Interleukin-1 receptor-like 1 is produced by our Mammalian expression system and the target gene encoding Ser27-Ala337 (Val192Ala) is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: Receptor for interleukin-33 (IL-33), signaling requires association of the coreceptor IL1RAP (PubMed:18450470, PubMed:17675517, PubMed:29045903). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. [The UniProt Consortium]