Mouse ITPRIPL1 (C-6His-Avi), biotinylated

Biotinylated Recombinant Mouse Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 is produced by our Mammalian expression system and the target gene encoding His17-Gly96 is expressed with a 6His, Avi tag at the C-terminus. Protein function: Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. [The UniProt Consortium]